The Arizona Cardinals visit the San Francisco 49ers on Sunday, September 27, 2026 at 4:05 p.m. ET from Levi’s Stadium, Santa Clara, CA. Arizona is 1-1 after a 31-7 loss to Seattle and San Francisco is 2-0 after a Week 2 win over Miami.
San Francisco averages 31 points and 380.5 yards per game and ranks among the league leaders on third down. Arizona averages 16.5 points per game with 179 passing yards and 93 rushing yards per game.
San Francisco allows 10 points per game with 4 sacks. Arizona allows 22.5 points per game and carries a plus-2 turnover margin.
The 49ers are 8.5-point favorites over the Cardinals.
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